Such significant issues as the administrative and financial integrity of Astan Quds Razavi as a divine institution, the creation of hereditary positions like teaching, and the allocation of salaries and duties to the employees of this organization over the Safavid era pose the questions that how teachers and scientists were given the responsibilities in the scientific centers and schools of the holy Shrine, how much, and from what sources they were paid. This study claimed that teachers of the schools and centers of the holy Shrine and its other related centers were appointed and paid by the kings of Safavid dynasty (907-1148 AH). Taking a descriptive-analytical method and relying on archival documents, this study revealed that a man titled “motavallibashi” (custodian) under the supervision of the Safavid kings was appointed to handle the endowments and regulations of Astan Quds Razavi. This way, this institution was organized to have a systematic administrative and civil structure. By Shah Tahmasb Safavi’s order the teachers were appointed and their salaries were paid. Consequently, the position of a teaching came to be one of the official and hereditary positions of Astan Quds Razavi. The surviving documents about the teachers working in this era are mainly financial documents that include information on the salaries, benefits, sources of the salaries, and payment of duties to the descendants. Moreover, the documents include some information on how teachers were appointed and their decrees of appointment were issued.